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You Really Know Procaine CAS 59-46-1?

Procaine CAS 59-46-1

Procaine CAS 59-46-1Common dosage forms are tablets and injections. For local anesthetic. It is used for infiltration anesthesia, block anesthesia, lumbar anesthesia, epidural anesthesia and closed therapy, and is also used to relieve the symptoms of neurasthenia, neurasthenia syndrome and autonomic dysfunction.

Element

The main ingredient of this product is procaine hydrochloride.

Character

Procaine hydrochloride tablets:

sugar-coated tablets, white or off-white after removing the coating.

Procaine Hydrochloride Injection:

Colorless clear liquid.

Indications

Procaine Hydrochloride Tablets:

This product is used to relieve the symptoms of neurasthenia, neurasthenia syndrome and autonomic dysfunction.

Procaine Hydrochloride Injection:

This product is suitable for infiltration anesthesia, block anesthesia, lumbar anesthesia, epidural anesthesia and block therapy, etc.

pharmacological effect

1.This product is an ester local anesthetic, which can temporarily block the conduction of nerve fibers and has an anesthetic effect. This product has weak penetrating power to the skin and mucous membranes, so it is not suitable for topical anesthesia. This product has poor diffusion and permeability, and its hydrochloride combined form releases free base in the tissue to exert local anesthetic effect.

2.This product has constant inhibition and excessive excitement on the central nervous system. It first causes sedation, dizziness, and increased pain threshold, followed by dizziness, disorientation, and ataxia, and the central inhibition continues to deepen, resulting in slow perception, blurred consciousness, and then enters a coma. If the dose continues to increase, symptoms of central nervous system excitement such as muscle tremors, irritability, and convulsions may appear.

3.Small doses of this product can excite sympathetic nerves, increase heart rate and blood pressure, and increase the dose. Due to myocardial inhibition, peripheral vasodilation, and mild ganglion blockage, blood pressure will drop and heart rate will increase.

4.This product inhibits the release of acetylcholine in the presynaptic membrane, produces certain neuromuscular blockade, can enhance the effect of non-depolarizing muscle relaxants, and directly inhibit smooth muscle, which can relieve smooth muscle spasm.

Pharmacokinetics

1.When procaine enters the body, it is quickly absorbed and distributed, and the drug effect is maintained for about 30-60 minutes. Most of it is combined with plasma proteins and accumulates in skeletal muscle, red blood cells and other tissues. When the plasma concentration decreases, it is redistributed to whole body.

2.In the blood circulation, most of them are rapidly hydrolyzed by pseudocholinesterase in plasma to produce p-aminobenzoic acid and diethylaminoethanol. The former is 80% in the original form and combined form, and the latter is only 30% excreted by the kidneys. The rest Hydrolyzed by liver esterase, further degraded and then excreted with urine.

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